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There was no working experience so far with the usage of METROGEL-VAGINAL in Expecting people. Metronidazole crosses the placental barrier and enters the fetal circulation promptly. No fetotoxicity or teratogenicity was observed when metronidazole was administered orally to Expecting mice at six moments the proposed human dose (based upon mg/m²); however, in only one smaller research exactly where the drug was administered intraperitoneally, some intrauterine deaths have been noticed. The relationship of those results for the drug is unfamiliar.
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Utilization of cimetidine with oral metronidazole may extend the 50 %-existence and reduce plasma clearance of metronidazole.
Due to the potential for tumorigenicity revealed for metronidazole in mouse and rat scientific tests, a decision need to be manufactured regardless of whether to discontinue nursing or to discontinue the drug, considering the necessity of the drug on the mom.
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